Malegra 100mg can be taken orally and work by blocking PDE - 5 an enzyme that breaks down a chemical called cGMP inside the penile area. This chemical can be responsible for relaxing muscles in the penile area, allowing full of blood flow and becoming erect. By blocking PDE-5, malegra 100 can keep the cGMP level high enough to maintain an erection even when cannot stimulate. It can take about 30 minutes to take effect.